Adult Rheumatoid Arthritis (RA): ORENCIA® (abatacept) is a prescription
medicine that reduces signs and symptoms in adults with moderate to severe
RA, including those who have not been helped enough by other medicines for
RA. ORENCIA may prevent further damage to your bones and joints and may help
your ability to perform daily activities. In adults, ORENCIA may be used
alone or with other RA treatments other than Janus kinase (JAK) inhibitors
or biologic disease-modifying antirheumatic drugs (bDMARDs), such as tumor
necrosis factor (TNF) antagonists.
The concomitant use of ORENCIA with other potent immunosuppressants [e.g., bDMARDs,
JAK inhibitors] is not recommended.
Polyarticular Juvenile Idiopathic Arthritis (pJIA): ORENCIA reduces
signs and symptoms in patients 2 years of age and older with moderate to
severe polyarticular JIA. ORENCIA may be used alone or with methotrexate
(MTX).
The concomitant use of ORENCIA with other potent immunosuppressants [e.g., bDMARDs,
JAK inhibitors] is not recommended.
It is not known if ORENCIA is safe and effective in children less than two years of age for the treatment of pJIA
or PsA.
Psoriatic Arthritis (PsA): ORENCIA is used to reduce signs and symptoms of active Psoriatic Arthritis in people 2 years of age and older. In adults, ORENCIA may be used alone or with other non-biologic PsA treatments. In children, ORENCIA can be used alone or with methotrexate.
The concomitant use of ORENCIA with other potent immunosuppressants [e.g., bDMARDs,
JAK inhibitors] is not recommended.
It is not known if ORENCIA is safe and effective in children less than two years of age for the treatment of pJIA or PsA.